Pediatric anesthesia & critical care
Hypothermia after extracorporeal cardiopulmonary resuscitation not associated with improved neurologic complications or survival in children: An analysis of the Extracorporeal Life Support Organization (ELSO) registry
Main findingResult — go to the resultAdjusted odds ratio 1.10 95% CI 0.80–1.51Authors' conclusion
Analysis of a large, multicenter, international dataset demonstrates that hypothermia for greater than 24 hours among children who undergo ECPR is not associated with decreased neurologic complications or mortality benefit at time of hospital discharge.
Study context
- Population
- Children treated with extracorporeal cardiopulmonary resuscitation (ECPR), ELSO international registry, 2011–2019
- Participants
- 2,289 ECPR encounters
- Exposure
- Hypothermia vs no hypothermia after ECPR
- Outcome
- Composite of neurologic complications (brain death, seizures, infarction, hemorrhage, diffuse ischemia)
Methodological detailsmulticenter, registry (ELSO)
- Multicenter
- Registry (ELSO)
Main finding
As reported in the abstract
Adjusted odds ratio
1.10
95% CI 0.80–1.51
Hypothermia vs Non-hypothermia
AOR 1.10 (95% CI 0.80–1.51)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | AOR (95% CI) | |
|---|---|---|
| Mortality on ECMO | 0.76 (0.59–0.97) | |
| Mortality prior to hospital discharge | 0.96 (0.76–1.21) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Hypothermia after extracorporeal cardiopulmonary resuscitation not associated with improved neurologic complications or survival in children: An analysis of the ELSO registry. Resuscitation. Published 27 May 2023. doi:10.
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