Identifying predictors of neuropathic pain medication prescribing, adherence, and discontinuation: a systematic review and meta-analysis
Authors' conclusion
Adherence can be improved by using dose titration and medicine reminders.
Study context
- Population
- Adults with neuropathic pain69 studies
- Outcome
- Predictors of pain medication prescribing, adherence, and discontinuation
Pooled result
As reported in the abstract
- Predictors of being prescribed recommended neuropathic pain medications: mental health disorder, DM, White race
- Predictors of better adherence: serotonin-norepinephrine reuptake inhibitors vs gabapentinoids or tricyclic antidepressants, dose titration, medicine reminder
- Predictors of higher likelihood of discontinuation: tricyclic antidepressants vs other antidepressants, combination of neuropathic pain medications vs monopharmacotherapy
- 53 studies on prescribing, 14 on adherence, 27 on discontinuation (non-mutually exclusive)
Original publication
Identifying predictors of neuropathic pain medication prescribing, adherence, and discontinuation: a systematic review and meta-analysis. Br J Anaesth. Published 27 November 2025. doi:10.
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