Impact of the 2017 revised Japanese obstetric hemorrhage management guidelines on tranexamic acid use in patients undergoing cesarean delivery: an interrupted time series analysis
Main finding · Rate of TXA useResult — go to the resultQuarterly percentage change 0.48% 95% CI 0.36–0.60Authors' conclusion
This interrupted time series analysis demonstrated a significant increase in the rate of tranexamic acid administration following the implementation of the revised guidelines, reversing the previously observed downward trend.
Study context
- Population
- Patients undergoing cesarean delivery in Japan, April 2012 to August 2021
- Participants
- 91,166 cesarean deliveries
- Exposure
- Prior to the guideline implementation vs Post-guidelines implementation
- Outcome
- Rate of TXA use
Methodological detailsnationwide health insurance claims database
- Nationwide health insurance claims database
Main finding
As reported in the abstract
Quarterly percentage change
0.48%
95% CI 0.36–0.60
P < 0.001
Post-guidelines vs Pre-guidelines
quarterly percentage change 0.48% (95% CI 0.36–0.60); P < 0.001
Observational data: associations, not effects.
Further findings
- Guidelines implementation not significantly associated with a change in the rate of transfusions
Original publication
Impact of the 2017 revised Japanese obstetric hemorrhage management guidelines on tranexamic acid use in patients undergoing cesarean delivery: an interrupted time series analysis. Int J Obstet Anesth. Published 30 August 2024. doi:10.
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