Impact of Lactate Clearance on Clinical and Neurological Outcomes of Patients With Out-of-Hospital Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Secondary Data Analysis*
Authors' conclusion
In patients with OHCA who underwent ECPR, an increase in the modified 6-hour LC was associated with favorable clinical and neurologic outcome.
Study context
- Population
- Patients with out-of-hospital cardiac arrest (OHCA) receiving extracorporeal cardiopulmonary resuscitation (ECPR) at 36 hospitals in Japan, 2013–2018
- Participants
- 1,227 patients · 36 hospitals
- Exposure
- Modified 6-hour lactate clearance quartiles Q2–Q4 vs Q1
- Outcome
- 30-day survival
- Follow-up
- 30 days
Methodological detailssecondary data analysis
- Secondary data analysis
Main finding
As reported in the abstract
- 30-day survival increased as 6-hour lactate clearance (LC) increased (p for trend)
- P for trend < 0.001
Observational data: associations, not effects.
Further findings
Favorable neurologic outcome
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Modified 6-hour LCMultivariate analysis | 1.002 (1.000–1.004) | P = 0.027 | |
| 0.512Adjusted odds ratio (log scale) |
- Favorable neurologic outcome: multivariate analysis; higher LC associated with favorable neurologic outcome
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of Lactate Clearance on Clinical and Neurological Outcomes of Patients With Out-of-Hospital Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Secondary Data Analysis*. Crit Care Med. Published 27 February 2024. doi:10.
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