Neuroanesthesia & neurocritical care
Impact of age and mean intracranial pressure on the morphology of intracranial pressure waveform and its association with mortality in traumatic brain injury
Authors' conclusion
AmpICP and PSI capture distinct aspects of cerebrospinal compliance. PSI appears to reflect age-related stiffening of the cerebrovascular system, while AmpICP, influenced by mean ICP, indicates acute volume compensatory changes.
Study context
- Population
- Traumatic brain injury (TBI) patients with intracranial pressure (ICP) recordings (median age 50 (30, 61) years)
- Participants
- 183 patients
- Outcome
- Impact of age and mean ICP on shape (PSI) and amplitude (AmpICP) of ICP pulse waveform
Methodological detailsCENTER-TBI database, factorial ANOVA, multiple regression
- CENTER-TBI database
- Factorial ANOVA
- Multiple regression
Main finding
As reported in the abstract
Determinants of PSI and AmpICP (variance explained)
- Age on pulse shape index (PSI), % of variance (p < 0.01)
- 33.1%
- Mean ICP on PSI, % of variance (p < 0.01)
- 6.6%
- Mean ICP on AmpICP, % of variance (p < 0.01)
- 22.8%
- Age on AmpICP, % of variance (p < 0.01)
- 8.0%
- Combined age and mean ICP on AmpICP, % of variance (p = 0.01); no influence on PSI
- 11.7%
Observational data: associations, not effects.
Further findings
Multiple regression adjusted for Rotterdam CT score
- Age on PSI, β (p < 0.01)
- 0.342
- Mean ICP on AmpICP, β (p < 0.01)
- 0.522
Association with mortality · six-month
- AmpICP AUC
- 0.76
- PSI AUC
- 0.71
- Moderately associated
Original publication
Impact of age and mean intracranial pressure on the morphology of intracranial pressure waveform and its association with mortality in traumatic brain injury. Crit Care. Published 17 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →