Perioperative medicine & outcomes
Impact of continuous serratus plane analgesia on quality of recovery after video-assisted thoracic surgery: a prospective double-blind, randomized, placebo-controlled trial
Authors' conclusion
In this prospective, double-blind, randomized, placebo-controlled trial, continuous SAPB catheter infusion did not improve the primary outcome (QoR-40), and the observed differences in secondary outcomes should be interpreted as exploratory.
Study context
- Population
- Adults undergoing elective video-assisted thoracoscopic surgery (VATS)173 analysed
- Participants
- 88 vs 85
- Comparison
- Serratus anterior plane block (SAPB) vs control
- SAPBn = 88
- Controln = 85reference
- Primary endpoint
- QoR-40 score
- Follow-up
- POD 1
Methodological detailsprospective, double-blind, placebo-controlled
- Prospective
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
SAPB
176
median · range 166–184
Control
172
median · range 159–183
P = 0.1036
Secondary outcomes
Opioid consumption in recovery (IV MME) · significantly reduced with SAPB
P = 0.0388
Opioid consumption on POD 1 (IV MME) · significantly reduced with SAPB
P = 0.0349
Quality of recovery (QoR-40) score, postoperative day (POD) 2-4
- Remained higher in SAPB across POD 2 to 4, not statistically significant
Hospital LOS
- LOS lower with SAPB by 0.8 days, not statistically significant (2.69±1.76 vs 3.50±4.01)
- P = 0.0872
Pain scores
- Similar between groups
Safety
Complications and 30-day readmissions
- Similar between groups
Original publication
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