Impact of different preferred functional outcomes on the results of the pre-hospital antifibrinolytics for traumatic coagulopathy and hemorrhage (PATCH-trauma) trial
Authors' conclusion
The assessment of TXA therapy's efficacy and safety may vary depending on scenarios where certain functional outcomes are considered worse than death.
Study context
- Population
- Severely injured patients at risk of acute traumatic coagulopathy, with complete 6-month outcomes
- Participants
- 1,107 participants
- Comparison
- Pre-hospital tranexamic acid (TXA) vs placebo
- TXAn = 561
- Placebon = 546reference
Methodological detailspost-hoc analysis, generalized pairwise comparisons
- Post-hoc analysis
- Generalized pairwise comparisons
Primary result
As reported in the abstract
Original 8-point GOS-E (WR) · 6 months
Original Glasgow Outcome Scale - Extended (GOS-E): neutral win ratio (WR)
1.03
95 % CI 0.90–1.19
Further findings
GOS-E with death ranked preferable to progressively less impaired functionality (vegetative state to upper moderate disability) (WR) · 6 months
- WR decreased
- 0.86 (95 % CI 0.75-1.00)
- WR >1 favours TXA
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of different preferred functional outcomes on the results of the pre-hospital antifibrinolytics for traumatic coagulopathy and hemorrhage (PATCH-trauma) trial. J Crit Care. Published 12 September 2025. doi:10.
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