Impact of false lumen volume on admission coagulopathy in acute type A aortic dissection
Main finding · Indexed false lumen volumeResult — go to the resultOdds ratio 1.38 per 10 mL/m² 95% CI 1.04–1.96Authors' conclusion
Indexed false lumen volume independently predicts preoperative coagulopathy in ATAAD and correlates with hemostatic disorders.
Study context
- Population
- Consecutive patients undergoing urgent surgery for acute type A aortic dissection (2019–2023) with preoperative coagulation sample and ECG-gated CT angiography
- Participants
- 55 patients
- Exposure
- Coagulopathy vs no coagulopathy at admission
- Coagulopathyn = 16
- Outcome
- Preoperative coagulopathy (PTr>1.2) and its association with indexed false lumen volume
- Follow-up
- Admission
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
Indexed false lumen volume
Odds ratio
1.38 per 10 mL/m²
95% CI 1.04–1.96
By group
Indexed false lumen volume
OR 1.38 per 10 mL/m² (95% CI 1.04–1.96)
Per 10 mL/m², as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Coagulopathy at admission
- 29% · 16
Coagulation factors, D-dimer, shock and malperfusion
- Coagulopathy: reduced factors II, V, VII, X and fibrinogen, higher D-dimer, more frequent shock and malperfusion
Correlations of false lumen volume
- Positive correlation with prothrombin time ratio (PTr); negative with fibrinogen, factor V, factor II and platelet count
Safety
- Markedly increased risk of major perioperative bleeding in patients with coagulopathy at admission vs those without
- 62.5% vs. 20.5%
- p = 0.004
Original publication
Impact of false lumen volume on admission coagulopathy in acute type A aortic dissection. Anaesth Crit Care Pain Med. Published 22 March 2026. doi:10.
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