Pediatric anesthesia & critical care
Implementation of an algorithm for tapering analgosedation reduces iatrogenic withdrawal syndrome in pediatric intensive care
Authors' conclusion
the prevalence of IWS was significantly lower in the intervention group in our study.
Study context
- Population
- Mechanically ventilated patients from newborn to 18 years with continuous opioid and benzodiazepine infusions for ≥5 days, two Norwegian Pediatric Intensive Care Units (PICUs) at Oslo University Hospital, May 2016–December 2021
- Participants
- 80 participants
- Exposure
- Algorithm for tapering analgosedation vs baseline
- Baselinen = 40reference
- Interventionn = 40
- Outcome
- Reduction in IWS (WAT-1 score ≥3)
Methodological detailsconsecutive inclusion, two centres, Age and diagnosis did not differ between groups
- Consecutive inclusion
- Two centres
- Age and diagnosis did not differ between groups
Main finding
As reported in the abstract
Prevalence of IWS
Observational data: associations, not effects.
Further findings
Median
| Outcome | Baseline | Intervention | P value |
|---|---|---|---|
| Peak WAT-1 score | 5.0 (IQR 4–6.8) | 3.0 (IQR 2.0–6.0) | P = 0.012 |
Iatrogenic withdrawal syndrome (IWS) burden over time (SUM WAT-1 ≥ 3)
- Reduction of IWS from a median of 15.5 (IQR 8.25-39) to a median of 3 (IQR 0-20)
- P = <.001
Original publication
Implementation of an algorithm for tapering analgosedation reduces iatrogenic withdrawal syndrome in pediatric intensive care. Acta Anaesthesiol Scand. Published 7 June 2023. doi:10.
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