Improving Outcomes After Post–Cardiac Arrest Brain Injury: A Scientific Statement From the International Liaison Committee on Resuscitation

Future trials must tailor interventions to the patients most likely to benefit and deliver them at the appropriate time, route and dose.

Multimodal neuroprotective therapies are more likely than monotherapies to succeed.

Biomarkers should be developed to identify patients with the targeted injury mechanism, quantify its severity and measure response to therapy.

Studies need to be adequately powered to detect realistic effect sizes meaningful to patients, families and clinicians.

Study designs should be optimized to accelerate evaluation of the most promising interventions.

Multidisciplinary and international collaboration will be essential to develop effective therapies.