Obstetric anesthesia

Incidence of Pain during Cesarean Delivery with Neuraxial Anesthesia: An International, Prospective Cohort Study

AnesthesiologyPublished Prospective cohort study

Authors' conclusion

The overall incidence of patient-reported pain during cesarean delivery with neuraxial anesthesia in this multicenter cohort was 7.6%. This varied significantly by anesthesia technique, with spinal having the lowest incidence and epidural top-up having the highest.

Study context

Population
Patients undergoing cesarean delivery with neuraxial anesthesia, 15 centers in the US and Canadaincluded in the analysis
Participants
3,693 patients
Outcome
Incidence of patient-reported pain during cesarean delivery with neuraxial anesthesia
Methodological detailsinternational, multicenter, Conducted over 8 weeks
  • International
  • Multicenter
  • Conducted over 8 weeks

Main finding

As reported in the abstract

Patient-reported pain during cesarean delivery

Overall incidence

7.6%

282 of 3,693 patients; 95% CI 6.8 to 8.5%

Observational data: associations, not effects.

Further findings

Intraoperative pain by technique, elective cesarean delivery (subgroup)

Spinal
3.7% (95% CI 2.7 to 5.0%)
Combined spinal-epidural
9.2% (95% CI 6.7 to 12.2%)
Epidural top-up
12.2% (95% CI 4.1 to 26.2%)

Intraoperative pain by technique, non-elective cesarean delivery (subgroup)

Spinal
5.7% (95% CI 4.0 to 7.8%)
Combined spinal-epidural
7.1% (95% CI 4.7 to 10.1%)
Dural puncture epidural
8.0% (95% CI 2.2 to 19.2%)
Epidural top-up
13.2% (95% CI 11.1 to 15.5%)

Pain NRS (0 to 10) in patients with intraoperative pain

Median NRS (IQR 4 to 8)
6

Dissatisfaction with pain management by anesthesia team, among those with pain

Dissatisfied patients, 29
10.3%

Original publication

Incidence of Pain during Cesarean Delivery with Neuraxial Anesthesia: An International, Prospective Cohort Study. Anesthesiology. Published 24 November 2025. doi:10.1097/aln.0000000000005868

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