Induction Agents for Tracheal Intubation in Critically Ill Patients
Authors' conclusion
Although no definitive conclusions can be drawn based on the available evidence, recent evidence pointed out the potential negative effect of etomidate on survival and the association of propofol with cardiovascular instability.
Study context
- Population
- Critically ill patients undergoing tracheal intubationRCTs and observational studies
- Comparison
- Etomidate vs ketamine vs propofol as induction agents
Methodological detailsconcise definitive review, PubMed search
- Concise definitive review
- PubMed search
Main finding
As reported in the abstract
- Etomidate may carry a non-negligible mortality risk without definitive hemodynamic benefits vs ketamine
- Large observational study: propofol associated with post-intubation cardiovascular instability
- No multicentre RCTs compare propofol with other induction agents
Original publication
Induction Agents for Tracheal Intubation in Critically Ill Patients. Crit Care Med. Published 22 November 2024. doi:10.
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