Neuroanaesthesia & neurocritical care
Interaction Between Admission Hemoglobin and Sex on ICU Mortality in Patients With Moderate-to-Severe Traumatic Brain Injury: A Retrospective Bicentric Cohort Study
Main finding · ICU mortality: sex × hemoglobin interactionResult — go to the resultOdds ratio 1.04 97.5% CI 0.91–1.19Authors' conclusion
No interaction between admission hemoglobin and sex was found regarding ICU mortality following TBI in this cohort.
Study context
- Population
- Adult critically ill patients with moderate-to-severe traumatic brain injury (TBI), two level 1 trauma centers in France, November 2010 to July 2025
- Participants
- 5,513 patients
- Exposure
- Interaction of admission hemoglobin and sex on ICU mortality
- Outcome
- ICU mortality: sex × hemoglobin interaction
Methodological detailsbicentric
- Bicentric
Main finding
As reported in the abstract
Odds ratio
1.04
97.5% CI 0.91–1.19
P = 0.433
Sex × hemoglobin interaction
OR 1.04 (97.5% CI 0.91–1.19); P = 0.433
Observational data: associations, not effects.
Further findings
Sex-specific difference in standardized ICU mortality risk at equivalent admission Hb (causal inference methods)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| SexNo evidence of a sex-specific difference | 1.01 (0.85–1.19) | P = 0.936 | |
| 0.512Adjusted odds ratio (log scale) |
Predicted ICU mortality risk by sex
- Lower in females across all Hb levels (Wald tests, all p < 0.05 from 9.0 to 13.0 g/dL)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Interaction Between Admission Hemoglobin and Sex on ICU Mortality in Patients With Moderate-to-Severe Traumatic Brain Injury: A Retrospective Bicentric Cohort Study. Crit Care Med. Published 28 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →