Perioperative medicine & outcomes
Intraoperative blood pressure targeting in noncardiac surgery: a Bayesian random-effects meta-analysis of randomized trials
Authors' conclusion
Protocolized intraoperative arterial pressure-targeting strategies did not demonstrate a consistent incremental benefit over contemporary usual care in major noncardiac surgery.
Study context
- Population
- Adults undergoing major noncardiac surgery15 RCTs
- Comparison
- Pressure targeting vs Usual care
- Outcome
- All-cause mortality
Methodological detailsBayesian random-effects (prespecified primary framework), confirmatory frequentist analyses
- Bayesian random-effects (prespecified primary framework)
- Confirmatory frequentist analyses
Pooled result
As reported in the abstract
All-cause mortality (13 trials)
Frequentist OR, pressure targeting vs usual care
1.00
95% CI 0.83–1.21
Bayesian median OR, pressure targeting vs usual care
1.00
95% CrI 0.73–1.38
Bayesian prediction interval (OR)
0.56-1.78
Further pooled results
Acute kidney injury (AKI) (14 trials)
- Frequentist OR, pressure targeting vs usual care
- 0.87 (95% CI 0.73-1.03)
- Bayesian median OR, pressure targeting vs usual care
- 0.88 (95% CrI 0.70-1.05)
- Compatible with no clinically important benefit; moderate heterogeneity; sensitive to individual-trial exclusion in leave-one-out analyses
MINS (8 trials)
- Frequentist OR, pressure targeting vs usual care
- 1.04 (95% CI 0.93-1.15)
- Bayesian median OR, pressure targeting vs usual care
- 1.05 (95% CrI 0.90-1.26)
- Compatible with no treatment effect
Exploratory analyses
- Any potential renal benefit may depend on the broader hemodynamic context in which arterial pressure targets are implemented
Original publication
Intraoperative blood pressure targeting in noncardiac surgery: a Bayesian random-effects meta-analysis of randomized trials. Anesthesiology. Published 28 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →