Intraoperative hydromorphone decreases postoperative pain: an instrumental variable analysis
Main finding · Admission PACU pain score per 0.2-mg increase in intraoperative hydromorphoneResult — go to the resultMean difference −0.8 95% CI −1.2 to −0.4Authors' conclusion
This study suggests that intraoperative administration of intermediate-duration opioids does not cause the same effects as short-acting opioids with respect to postoperative pain.
Study context
- Population
- Patients who received intraoperative hydromorphone
- Participants
- 6,750 patients
- Exposure
- Higher vs lower intraoperative hydromorphone dose
- Outcome
- Postoperative pain scores and opioid administration
Methodological detailsinstrumental variable analysis, two-stage least squares regression
- Instrumental variable analysis
- Two-stage least squares regression
Main finding
As reported in the abstract
Admission PACU pain score per 0.2-mg increase in intraoperative hydromorphone
Mean difference
−0.8
95% CI −1.2 to −0.4
P < 0.001
0.2-mg increase in intraoperative hydromorphone
mean difference −0.8 (95% CI −1.2 to −0.4); P < 0.001
Per 0.2-mg increase in intraoperative hydromorphone, as printed
Observational data: associations, not effects.
Further findings
Maximum and time-weighted mean pain scores · 2 days postoperatively
- Decreased with a 0.2-mg increase in intraoperative hydromorphone
Postoperative opioid administration
- Not increased
Original publication
Intraoperative hydromorphone decreases postoperative pain: an instrumental variable analysis. Br J Anaesth. Published 12 April 2023. doi:10.
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