Intraoperative hypotension is associated with decreased long-term survival in older patients after major noncardiac surgery: Secondary analysis of three randomized trials
Authors' conclusion
In older patients who underwent major noncardiac surgery mainly for cancer, intraoperative hypotension was associated with worse overall, recurrence-free, and event-free survivals.
Study context
- Population
- Patients aged 60 to 90 years after major noncardiac thoracic or abdominal surgery (≥ 2 h), mainly for cancer, 17 tertiary hospitals in China
- Participants
- 2,664 patients · 3 RCTs
- Comparison
- Cumulative duration or area under mean arterial pressure (MAP) < 60 mmHg: >10 min vs <1 min; >30 vs <1 mmHg⋅min
- Primary endpoint
- Overall survival
Methodological detailslong-term follow-up, multicentre
- Long-term follow-up
- Multicentre
Primary result
As reported in the abstract
AHR for shortened overall survival (death) (95% CI)P value
Duration >10 min vs Duration <1 min
1.31(1.09–1.57)
P = 0.004Area >30 mmHg⋅min vs Area <1 mmHg⋅min
1.40(1.16–1.68)
P < 0.001Secondary outcomes
Recurrence-free and event-free survival
- Similar associations for duration > 10 min or area > 30 mmHg⋅min under MAP < 60 mmHg
Original publication
Intraoperative hypotension is associated with decreased long-term survival in older patients after major noncardiac surgery: Secondary analysis of three randomized trials. J Clin Anesth. Published 1 July 2024. doi:10.
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