Perioperative medicine & outcomes
Intravascular volume status and stress markers in patients observing long and short duration of fasting: A prospective single blinded observational study
Authors' conclusion
Stress markers levels show significant elevation in the perioperative period, maximum over the study duration, but this change is similar in both the groups.
Study context
- Population
- ASA I and II patients undergoing elective laparoscopic cholecystectomy
- Participants
- 70 participants
- Exposure
- Long fasting vs short fasting
- Long fasting (LF)n = 35
- Short fasting (SF)n = 35reference
- Outcome
- Intravascular volume depletion (IVCCI)
Methodological detailssingle-blind
- Single-blind
Main finding
As reported in the abstract
95% CI 8.47–11.18; P < 0.001
Observational data: associations, not effects.
Further findings
Correlation of inferior vena cava collapsibility index (IVCCI) with fasting duration
- Pearson's correlation r
- 0.69
- P
- P < 0.001
Stress markers (C-reactive protein (CRP), free T4, C-peptide) over study duration
- CRP significantly elevated over time
- <0.001
- Free T4 significantly elevated over time
- <0.001
- C-peptide significantly elevated over time
- 0.03
- Increase similar in both groups (covariates IVCCI, age, gender)
- Repeated measures ANCOVA
Original publication
Intravascular volume status and stress markers in patients observing long and short duration of fasting: A prospective single blinded observational study. J Clin Anesth. Published 3 November 2022. doi:10.
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