Neuroanesthesia & neurocritical care
Liberal versus restrictive transfusion strategies in subarachnoid hemorrhage: a secondary analysis of the TRAIN study
Primary resultResult — go to the resultRelative risk 0.87 95% CI 0.71–1.04Authors' conclusion
A liberal transfusion strategy was not associated with a lower incidence of unfavorable outcome after SAH when compared to a restrictive strategy.
Study context
- Population
- Subarachnoid hemorrhage (SAH) patients from the TRAIN trial188 analysed
- Participants
- 190 patients
- Comparison
- Liberal vs restrictive RBC transfusion strategy
- Liberaln = 86
- Restrictiven = 102reference
- Primary endpoint
- Unfavorable neurological outcome (Glasgow Outcome Scale Extended 1-5)
- Follow-up
- 180 days
Methodological detailspre-planned secondary analysis, Liberal group older than restrictive group; otherwise similar baseline characteristics
- Pre-planned secondary analysis
- Liberal group older than restrictive group; otherwise similar baseline characteristics
Primary result
As reported in the abstract
Relative risk
0.87
95% CI 0.71–1.04
Events by treatment group
Liberal vs Restrictive
RR 0.87 (95% CI 0.71–1.04)
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Cerebral ischemiaSignificantly lower risk | 0.63 (0.41–0.97) | |
| Unfavorable outcome, multivariate analysisAdjusted for confounders | 0.83 (0.70–0.99) | |
| 0.512Relative risk (log scale) |
Transfusion and hemoglobin (Hb)
- Liberal group received more red blood cell transfusions (RBCT) and had higher Hb levels over time
Original publication
Liberal versus restrictive transfusion strategies in subarachnoid hemorrhage: a secondary analysis of the TRAIN study. Crit Care. Published 7 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →