Perioperative medicine & outcomes
Long-term outcomes of time-dependent phenotypes of perioperative myocardial injury☆
Main finding · MACCEResult — go to the resultAdjusted odds ratio 3.5 95% CI 2.0–5.9Authors' conclusion
Increased hs-cTnT based on timing identifies prognostically important subgroups. Perioperative increases, regardless of preoperative levels, are associated with a high risk of MACCE that is sustained up to 3 yr after surgery.
Study context
- Population
- Patients aged ≥50 yr undergoing major noncardiac surgery
- Participants
- 1,290 patients
- Exposure
- Time-dependent perioperative myocardial injury (PMI) phenotypes vs no High-sensitivity cardiac troponin T (hs-cTnT) elevation
- Outcome
- MACCE and mortality
- Follow-up
- Up to 3 yr after operation
Main finding
MACCE · up to 3 yr
Adjusted odds ratio
3.5
95% CI 2.0–5.9
Normal preoperative hs-cTnT with perioperative elevation vs No hs-cTnT elevation
aOR 3.5 (95% CI 2.0–5.9)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| MACCE, normal preoperative hs-cTnT with perioperative elevation · 30 daysNormal preoperative hs-cTnT with perioperative elevation vs No hs-cTnT elevation · risk greatest at 30 days | 4.5 (2.3–8.8) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Mortality · up to 3 yr
- PMI associated with increased mortality, but not sustained after multivariable adjustment
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Long-term outcomes of time-dependent phenotypes of perioperative myocardial injury☆. BJA Open. Published 4 June 2025. doi:10.
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