Cardiac arrest & resuscitation
Lower versus higher blood pressure targets in comatose patients resuscitated from out‐of‐hospital cardiac arrest—Protocol for a secondary Bayesian analysis of the box trial
Study context
- Population
- Comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA) during intensive careBOX trial
- Participants
- 789 patients
- Planned comparison
- Lower vs higher BP targets
Methodological detailsBayesian logistic and linear regressions, weakly informative priors, skeptical and evidence-based priors in sensitivity analyses, heterogeneity of treatment effects assessment, Secondary outcomes: neurological outcome after 365 days, and plasma neuron-specific enolase after 48 h, Heterogeneity of treatment effects on mortality by lactate at admission, time to ROSC, primary shockable rhythm, age, hypertension, ST-elevation MI
- Bayesian logistic and linear regressions
- Weakly informative priors
- Skeptical and evidence-based priors in sensitivity analyses
- Heterogeneity of treatment effects assessment
- Secondary outcomes: neurological outcome after 365 days, and plasma neuron-specific enolase after 48 h
- Heterogeneity of treatment effects on mortality by lactate at admission, time to ROSC, primary shockable rhythm, age, hypertension, ST-elevation MI
No results yet. This paper sets out the design of a trial; its results are to come.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Lower versus higher blood pressure targets in comatose patients resuscitated from out‐of‐hospital cardiac arrest—Protocol for a secondary Bayesian analysis of the box trial. Acta Anaesthesiol Scand. Published 21 February 2024. doi:10.
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