Pediatric anesthesia & critical care
Medical Toxicology Consultations and Mortality Among Patients With Poisonings in the PICU
Authors' conclusion
In this study of patients with toxicological exposures requiring PICU care, having a medical toxicology consultation was associated with lower mortality and shorter LOS compared with not having a consultation
Study context
- Population
- Patients with toxicological exposures admitted to pediatric intensive care units (PICUs) in the Virtual Pediatric System (VPS) database, 135 US sites, January 2019 to June 2023
- Participants
- 52,836 patients · 135 US sites
- Comparison
- Medical toxicology consultation vs no consultation
- Consultationn = 2,857
- No consultationn = 49,979reference
- Primary endpoint
- Mortality in the PICU and in the hospital overall
Methodological detailsVirtual Pediatric System, multicentre registry, multilevel models, adjusted analysis
- Virtual Pediatric System
- Multicentre registry
- Multilevel models
- Adjusted analysis
Primary result
As reported in the abstract
Mortality
Consultation vs No consultationAdjusted odds ratio (95% CI)
Death in the PICU
0.36(0.20–0.63)
Mortality at any time during hospitalization
0.39(0.24–0.64)
Secondary outcomes
| Outcome | Log estimate (95% CI) |
|---|---|
| PICU LOS15% reduced | −0.16 (−0.21 to −0.11) |
| Hospital LOS10% reduced | −0.10 (−0.14 to −0.06) |
- PICU LOS: adjusted for all covariates and differences across hospital sites
- Hospital LOS: adjusted for all covariates and differences across hospital sites
Original publication
Medical Toxicology Consultations and Mortality Among Patients With Poisonings in the PICU. JAMA Netw Open. Published 3 February 2025. doi:10.
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