Melanin-Concentrating Hormone Is Associated With Delayed Neurocognitive Recovery in Older Adult Patients With Preoperative Sleep Disorders Undergoing Spinal Anesthesia
Authors' conclusion
In older adult patients with preoperative sleep disorders, MCH is associated with the occurrence of delayed neurocognitive recovery after surgery.
Study context
- Population
- Older adults (≥65 years) with preoperative sleep disorders (Pittsburgh Sleep Quality Index (PSQI) >5) undergoing elective total hip arthroplasty (THA) or total knee arthroplasty (TKA) under spinal anaesthesia, Inner Mongolia, China, 2021–2022
- Participants
- 156 adults
- Exposure
- Cerebrospinal fluid (CSF) and plasma melanin-concentrating hormone (MCH) levels vs delayed neurocognitive recovery
- Outcome
- Delayed neurocognitive recovery (MoCA <26 at POD7)
- Follow-up
- POD7
Methodological detailsmonocentric, multivariable logistic regression
- Monocentric
- Multivariable logistic regression
Main finding
As reported in the abstract
Delayed neurocognitive recovery
Odds ratio (95% CI)P value
CSF MCH (per 1 pg/mL increase)
1.16(1.09–1.23)
P < 0.001Plasma MCH (per 1 pg/mL increase)
0.92(0.86–0.98)
P = 0.003Per 1 pg/mL increase, as printed
- Incidence of delayed neurocognitive recovery
- 59 (37.8%)
Observational data: associations, not effects.
Original publication
Melanin-Concentrating Hormone Is Associated With Delayed Neurocognitive Recovery in Older Adult Patients With Preoperative Sleep Disorders Undergoing Spinal Anesthesia. Anesth Analg. Published 5 December 2023. doi:10.
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