Perioperative medicine & outcomes
Multicenter External Validation of the PIPRA Model for Postoperative Delirium in Older Adults
Authors' conclusion
In this large, multicenter cohort, the PIPRA model demonstrated acceptable, albeit not perfect, discrimination for predicting POD in older surgical patients and was able to stratify risk in current perioperative practice.
Study context
- Population
- Consecutive patients aged ≥60 years undergoing noncardiac, non-intracranial surgery at 4 hospitals in Switzerland and Germany
- Participants
- 1,179 patients · 4 hospitals
- Outcome
- Discrimination for POD
Methodological detailsexternal validation, multicentre, prespecified subgroup analysis
- External validation
- Multicentre
- Prespecified subgroup analysis
Main finding
As reported in the abstract
| Group | AUC |
|---|---|
| PIPRA | 0.73 (95% CI: 0.69-0.77) |
PIPRA
AUC0.73 (95% CI: 0.69-0.77)
- AUC of original development dataset
- 0.80 (95% CI: 0.77-0.82)
Observational data: associations, not effects.
Further findings
| Outcome | Structured POD prevention | No prevention |
|---|---|---|
| PIPRA discrimination by structured POD prevention (prespecified subgroup)Prespecified subgroup analysis | ||
| AUC | 0.64 (95% CI: 0.55-0.73) | 0.76 (95% CI: 0.72-0.81) |
Postoperative delirium (POD) incidence
- Patients who developed POD
- 174 (14.8%)
AUC in original development dataset (reference)
- AUC of the original development dataset
- 0.80 (95% CI: 0.77-0.82)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Multicenter External Validation of the PIPRA Model for Postoperative Delirium in Older Adults. Anaesth Crit Care Pain Med. Published 21 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →