Cardiac arrest & resuscitation
Multimodal assessment of favorable neurological outcome using neuron-specific enolase (NSE) levels and kinetics, EEG and SSEP in comatose patients after cardiac arrest
Authors' conclusion
In comatose patients after CA, a low NSE levels at 24, 48 h or 72 h, a decreasing trend in NSE over time, a benign EEG and a high N20 amplitude are robust markers of favorable outcome, reducing prognosis uncertainty.
Study context
- Population
- Patients comatose after discontinuation of sedation after cardiac arrest, with EEG and NSE at 24, 48 or/and 72 h
- Participants
- 215 participants
- Exposure
- NSE levels and kinetics, EEG and SSEP, separately and combined, for predicting good neurological outcome
- Good outcomen = 54
- Outcome
- Favorable neurological outcome (CPC 1-2)
- Follow-up
- 3 months
Methodological detailssingle-centre, tertiary cardiac arrest (CA) center, prospective registry, January 2017 to April 2024
- Single-centre
- Tertiary CA center
- Prospective registry
- January 2017 to April 2024
Main finding
As reported in the abstract
Good outcome (CPC 1-2)
Good outcome
54 patients
25.1%
Observational data: associations, not effects.
Further findings
NSE blood levels · 24 h
P < 0.001
NSE blood levels · 48 h
P < 0.001
Benign EEG pattern
P < 0.001
| Outcome | Good outcome | Poor outcome | P value |
|---|---|---|---|
| NSE blood levels · 72 h | 20 (IQR 15–30) µg/L | 184 (IQR 60–300) µg/l | P < 0,001 |
Original publication
Multimodal assessment of favorable neurological outcome using NSE levels and kinetics, EEG and SSEP in comatose patients after cardiac arrest. Crit Care. Published 11 April 2025. doi:10.
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