Cardiac arrest & resuscitation
Multimodal Prediction of Favorable Outcome After Cardiac Arrest: A Cohort Study*
Authors' conclusion
This study describes and externally validates a multimodal score, including clinical, EEG and biological items available within 72 hours, showing a high performance in identifying early comatose CA survivors who will reach functional independence at 3 months.
Study context
- Population
- Consecutive comatose adults admitted after cardiac arrest, two academic hospitals (Lausanne, Switzerland; Boston, MA), January 2016 to June 2021
- Participants
- 499 adults
- Outcome
- Prognostic performance of the multimodal score for CPC 1-2
- Follow-up
- 3 months
Methodological detailsretrospective analysis of prospectively collected data, two academic hospitals, cross-validation, external validation
- Retrospective analysis of prospectively collected data
- Two academic hospitals
- Cross-validation
- External validation
Main finding
As reported in the abstract
Sensitivity for Cerebral Performance Category (CPC) 1-2 at ≥4 of 6 points
97.5%
95% CI 92.9–99.5%
Accuracy at ≥4 of 6 points
77.5%
95% CI 72.7–81.8%
AUC
0.88
95% CI 0.85–0.91
Observational data: associations, not effects.
Further findings
Score performance in validation cohort
- Similar performances in the validation cohort
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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