Neuroanaesthesia & neurocritical care
Myelin Basic Protein Expressing Microparticles Predict Neurologic Morbidity Risk From Acute Carbon Monoxide Poisoning
Authors' conclusion
MBP-MPs are an index for adverse outcome risk in CO-poisoned patients because they initiate an adaptive immune response.
Study context
- Population
- CO-poisoned patients presenting to two EDs114 CO-poisoned patients · 89 controls
- Participants
- 89 / 77 / 37
- Exposure
- CO-poisoned patients with neurologic sequelae (NS) vs CO-recovered vs controls
- Controlsn = 89reference
- CO-recoveredn = 77
- CO with NSn = 37
- Outcome
- MBP-bearing microparticles (MBP-MPs/μL) in blood at hospital presentation as predictor of neurologic sequelae
- Follow-up
- 1 month
Methodological detailsretrospective and prospective, two emergency departments, age and sex matched controls
- Retrospective and prospective
- Two emergency departments
- Age and sex matched controls
Main finding
As reported in the abstract
MBP-MPs/μL
CO-recovered vs Controls: P < 0.001 · CO with NS vs Controls and CO-recovered: P < 0.001
Observational data: associations, not effects.
Further findings
Murine CO-poisoning model
- Brain-derived MBP-MPs sensitized peripheral lymphocytes; with neutrophil-mediated blood-brain barrier disruption, triggered neuroinflammation
- Neuroinflammation also in naive mice injected with MBP-MPs from CO-exposed mice, not from controls
- No neuroinflammation in myelin basic protein (MBP)-tolerant, cervical lymphatic-ligated, neutropenic or recombinant plasma gelsolin-treated mice
Original publication
Myelin Basic Protein Expressing Microparticles Predict Neurologic Morbidity Risk From Acute Carbon Monoxide Poisoning. Crit Care Med. Published 3 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →