Naloxone Use in Novel Potent Opioid and Fentanyl Overdoses in Emergency Department Patients
Primary result · Naloxone boluses in-hospitalResult — go to the resultCohen d 0.78Authors' conclusion
In this cohort study of patients admitted to the ED with confirmed opioid overdose testing positive for NPOs, in-hospital naloxone dosing was high compared with patients who tested positive for fentanyl alone.
Study context
- Population
- Adults in the emergency department (ED) with presumed acute opioid overdose (OD) and residual blood samples, ToxIC Fentalog cohort, 2020 to 2022537 with complete laboratory data
- Participants
- 717 adults
- Comparison
- NPO-positive vs fentanyl-only overdose
- NPOn = 9
- Fentanyln = 11reference
- Primary endpoint
- Total number of naloxone doses and total cumulative naloxone dose administered in routine clinical care after the OD
Methodological detailsnationwide, ongoing cohort (ToxIC Fentalog)
- Nationwide
- Ongoing cohort (ToxIC Fentalog)
Primary result
Naloxone boluses in-hospital
Cohen d
0.78
P = 0.02
By group
NPO
1.33
mean · SD 1.50
Fentanyl
0.36
mean · SD 0.92
As reported in the abstract
Further findings
| Outcome | Values |
|---|---|
| Naloxone doses, metonitazene cases (subgroup) | Metonitazene mean 3.0 (SD 0) |
Naloxone doses, metonitazene cases (subgroup)
- Metonitazene OD associated with cardiac arrest and more naloxone doses overall
Safety
| Outcome | Values |
|---|---|
| CPR, metonitazene overdoses | Metonitazene 100% |
- CPR, metonitazene overdoses: 2 of 2 patients
Original publication
Naloxone Use in Novel Potent Opioid and Fentanyl Overdoses in Emergency Department Patients. JAMA Netw Open. Published 1 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →