Pediatric anesthesia & critical care
Neurodevelopment at 10 months and 2–3 years old after early and prolonged anaesthesia in infancy: General Anaesthesia & Brain Activity study (General Anaesthesia & Brain Activity (GABA)) secondary analysis
Authors' conclusion
Children with early prolonged general anaesthesia showed BSID scores comparable to age-matched controls.
Study context
- Population
- Infants exposed to GA planned for >2 h in the first 2 months of life, and unexposed children
- Participants
- 31 vs 59
- Comparison
- Early prolonged GA vs no GA exposure
- General anaesthesian = 31
- Unexposedn = 59reference
- Primary endpoint
- Bayley Scales of Infant and Toddler Development-III (BSID) assessments
- Follow-up
- 10 months, 2-3 yr
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
BSID cognition composite score
SMD
0.27
P adj=0.566
10 months; similar
SMD
0.25
P adj=0.651
2-3 yr; similar
Further findings
BSID motor composite score · 10 months
- Motor scores similar between cohorts, within typical reference ranges (SMD)
- 0.13
- P adj
- 1
- Adjusted P
BSID language composite score · 10 months
- Language scores similar between cohorts, within typical reference ranges (SMD)
- 0.19
- P adj
- 0.806
- Adjusted P
Association of BSID cognition scores with cumulative hours of GA (linear regression)
- No association at 10 months (R; P=0.635)
- 0.06
- No association at 2-3 yr (R; P=0.293)
- −0.13
Original publication
Neurodevelopment at 10 months and 2–3 years old after early and prolonged anaesthesia in infancy: General Anaesthesia & Brain Activity study (GABA) secondary analysis. BJA Open. Published 10 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →