Neuroanesthesia & neurocritical care
Neurological outcomes and mortality following hyperoxemia in adult patients with acute brain injury: an updated meta-analysis and meta-regression
Pooled resultResult — go to the resultUnadjusted odds ratio 1.295 95% CI 1.040–1.616Authors' conclusion
In our study we found that hyperoxemia is significantly associated with an increased risk of poor neurological outcomes and mortality in patients with acute brain injury compared to those with no hyperoxemia.
Study context
- Population
- Hospitalised adults with acute brain injury (e.g. TBI, post-cardiac arrest, SAH, intracerebral hemorrhage, ischemic stroke)
- Participants
- 16,635 adults · 24 studies
- Comparison
- Hyperoxemia vs no hyperoxemia
- Outcome
- Poor neurological outcome as defined by each study
Methodological detailsrandom-effects model, PRISMA, subgroup analyses, 66 studies fulfilled eligibility criteria for systematic review
- Random-effects model
- PRISMA
- Subgroup analyses
- 66 studies fulfilled eligibility criteria for systematic review
Pooled result
As reported in the abstract
Unadjusted odds ratio
1.295
95% CI 1.040–1.616
Hyperoxemia vs No hyperoxemia
unadjusted OR 1.295 (95% CI 1.040–1.616)
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| All-cause mortality (35 studies, 98,207 patients) | 1.13 (1.002–1.282) | |
| 0.512Odds ratio (log scale) |
Original publication
Neurological outcomes and mortality following hyperoxemia in adult patients with acute brain injury: an updated meta-analysis and meta-regression. Crit Care. Published 23 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →