Cardiac arrest & resuscitation
Neuroprognostication after cardiac arrest in patients without withdrawal of life-sustaining therapy: a prospective observational multicenter study
Authors' conclusion
In patients who remained comatose three days after CA and in whom multimodal prognosis becomes clinically relevant, guideline-recommended assessment identified poor-outcome patients with high specificity and consistency with prior multimodal prognostication cohorts.
Study context
- Population
- Adults comatose 72 h after cardiac arrest (CA) without withdrawal of life-sustaining therapy (WLST) during the first 4 weeks, 8 German hospitals, 2014–2017analysed
- Participants
- 101 participants
- Outcome
- Poor outcome (modified Rankin Scale score 4-6) predicted by guideline-recommended prognostic markers within 14 days
- Follow-up
- 12 months
Methodological detailsmulticentre
- Multicentre
Performance
As reported in the abstract
Poor outcome (modified Rankin Scale 4-6)
Poor outcome rate
67.3%
≥2 unfavourable markers within 14 days: no false positives; association with poor outcome (aOR)
34.7
Further findings
| Outcome | AUC |
|---|---|
| Prognostic discrimination with best CRS-R score added to established markersEstablished markers + best CRS-R vs Established markers · significantly improved | 0.925 vs. 0.888 |
Original publication
Neuroprognostication after cardiac arrest in patients without withdrawal of life-sustaining therapy: a prospective observational multicenter study. Crit Care. Published 24 July 2026. doi:10.
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