Cardiac arrest & resuscitation
No-Flow Duration and Outcomes After Cardiogenic Out-of-Hospital Cardiac Arrest in Older Adults
Authors' conclusion
In this cohort study of older adults with cardiogenic OHCA, the no-flow time window compatible with an estimated probability of at least 1% for favorable neurologic outcome became progressively shorter with advancing age.
Study context
- Population
- Adults ≥65 years with witnessed cardiogenic out-of-hospital cardiac arrest (OHCA) treated by Japan's nationwide emergency medical service (EMS) system, All-Japan Utstein Registry, 2010–2023of 1,795,502 registry cases
- Participants
- 259,851 adults
- Exposure
- No-flow duration by age group
- Outcome
- Favorable neurologic outcome (cerebral performance category 1 or 2)
- Follow-up
- 30 days
Methodological detailsnationwide, population-based, multicentre, observational, dynamic probability curves, Median age 82 (IQR, 75-88) years; 148 018 (57.0%) male; median no-flow time 11 (IQR, 8-15) minutes
- Nationwide
- Population-based
- Multicentre
- Observational
- Dynamic probability curves
- Median age 82 (IQR, 75-88) years; 148 018 (57.0%) male; median no-flow time 11 (IQR, 8-15) minutes
Main finding
As reported in the abstract
No-flow time at which estimated probability of favorable neurologic outcome fell below 1%
- All patients ≥65 years: no-flow time at which probability fell below 1%
- 11 (minutes; 95% CI 11-11)
- 30-day favorable neurologic outcome overall
- 8711 (3.4%)
Observational data: associations, not effects.
Original publication
No-Flow Duration and Outcomes After Cardiogenic Out-of-Hospital Cardiac Arrest in Older Adults. JAMA Netw Open. Published 1 September 2026. doi:10.
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