Perioperative medicine & outcomes

Non-invasive vs biological blood determination of haemoglobinemia for perioperative management: a systematic review with meta-analysis

J Clin Monit ComputPublished Systematic review and meta-analysis of diagnostic accuracy studies

Pooled result · Haemoglobin, non-invasive vs invasiveResult — go to the resultMD 0.13 g.dL-1 95% CI 0.10–0.36

Authors' conclusion

The results obtained support the reliability of pulsed co-oximetry.

Study context

Population
Perioperative patients; studies comparing non-invasive Hb measurement with invasive methods, January 2000 to February 2024
Participants
1,888 patients · 36 studies
Comparison
Non-invasive pulsed co-oximetry vs invasive biological Hb determination
Outcome
Diagnostic accuracy: MD in haemoglobin between non-invasive and invasive methods
Methodological detailsrandom-effects model, inverse variance method, sensitivity analyses, PRISMA, QUADAS-2 risk of bias
  • Random-effects model
  • Inverse variance method
  • Sensitivity analyses
  • PRISMA
  • QUADAS-2 risk of bias

Pooled result

Haemoglobin, non-invasive vs invasive

MD

0.13 g.dL-1

95% CI 0.10–0.36

P > 0.05

Non-invasive vs Invasive
MD 0.13 g.dL-1 (95% CI 0.10–0.36); P > 0.05

As reported in the abstract

Further pooled results

Sensitivity analyses (sampling site, sensor revision, location, risk of bias, population, study type)

No statistically significant difference between the two methods

Trending analysis

Acceptable in a majority of the studies

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Non-invasive vs biological blood determination of haemoglobinemia for perioperative management: a systematic review with meta-analysis. J Clin Monit Comput. Published 30 July 2025. doi:10.1007/s10877-025-01323-w

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