ICU sedation, delirium & recovery
Non‐response for health‐related quality of life outcomes in intensive care unit (ICU) patients: A systematic review of the reporting in randomised trials
Authors' conclusion
For HRQoL outcomes in ICU trials, we found that mortality at time of follow-up was high and non-response among survivors frequent.
Study context
- Population
- Randomised clinical trials (RCTs) in adult ICU patients reporting health-related quality of life (HRQoL) as an outcome196 outcomes from 88 RCTs
- Outcome
- Extent and pattern of missing HRQoL data and statistical handling of missing data and deaths
Methodological detailspublished protocol, risk of bias assessment in duplicate, Searched PubMed, EMBASE, CINAHL and Cochrane Library; RCTs published 2002-2022
- Published protocol
- Risk of bias assessment in duplicate
- Searched PubMed, EMBASE, CINAHL and Cochrane Library; RCTs published 2002-2022
Pooled result
As reported in the abstract
At follow-up
- Patients died by HRQoL follow-up, median (IQR 14%-39%)
- 27%
- Survivors not responding across outcomes, median (9%-38%)
- 20%
- Trials reporting numbers alive and eligible to respond
- 76%
- Outcomes analysed as complete cases only
- 80%
- Outcomes with handling of non-survivors reported
- 46%
- Outcomes reported as including non-survivors (value zero or worst possible score)
- 26%
Original publication
Non‐response for health‐related quality of life outcomes in ICU patients: A systematic review of the reporting in randomised trials. Acta Anaesthesiol Scand. Published 20 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →