Cardiac arrest & resuscitation
Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management
Authors' conclusion
Novel serum biomarkers reliably predicted poor neurological outcomes for patients with OHCA treated with TTM when life-sustaining therapy was not withdrawn.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients treated with TTM, biomarkers measured at 0, 24, 48 and 72 h after ROSCAugust 2018 to May 2020
- Participants
- 100 patients
- Exposure
- Novel (tau, NFL, glial fibrillary acidic protein (GFAP), UCH-L1) vs conventional (NSE, S-100B) serum biomarkers for predicting poor neurological outcome
- Outcome
- Poor neurological outcome
- Follow-up
- 6 months after OHCA
Methodological detailsdiagnostic/prognostic accuracy, SIMOA immunoassay
- Diagnostic/prognostic accuracy
- SIMOA immunoassay
Main finding
As reported in the abstract
Prediction of poor neurological outcome (AUC at 72 h after CA) · 72 h after CA
| Group | AUC | Sensitivity (95% CI 59.9-89.6) | Specificity |
|---|---|---|---|
| Tau | 0.906 | — not stated in the abstract | — not stated in the abstract |
| NFL | 0.946 | 77.1% | 100% |
| GFAP | 0.875 | — not stated in the abstract | — not stated in the abstract |
| UCH-L1 | 0.935 | — not stated in the abstract | — not stated in the abstract |
AUC
Tau0.906
NFL0.946
GFAP0.875
UCH-L10.935
Sensitivity (95% CI 59.9-89.6)
Tau— not stated in the abstract
NFL77.1%
GFAP— not stated in the abstract
UCH-L1— not stated in the abstract
Specificity
Tau— not stated in the abstract
NFL100%
GFAP— not stated in the abstract
UCH-L1— not stated in the abstract
— not stated in the abstract
- All conventional and novel serum biomarkers discriminated between good and poor neurological outcome groups
- P < 0.001
Observational data: associations, not effects.
Original publication
Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management. Crit Care. Published 16 March 2023. doi:10.
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