Cardiac arrest & resuscitation
NT-proBNP and neurologic outcomes in comatose survivors of out-of-hospital cardiac arrest
Main finding · Poor neurologic outcome (CPC 3-5)Result — go to the resultOdds ratio 2.50 95% CI 1.03–6.20Authors' conclusion
NT-proBNP was independently associated with neurologic outcome and survival to hospital discharge in comatose survivors of OHCA admitted to the ICU. When stratified by presenting rhythm, NT-proBNP was only associated with outcomes among patients with a shockable rhythm.
Study context
- Population
- Comatose patients admitted to the ICU after OHCA with NT-proBNP measured within 24 h of return of spontaneous circulation (2/1/2017 to 1/31/2020)
- Participants
- 301 patients
- Exposure
- NT-proBNP above vs below median
- Outcome
- Poor neurologic outcome (cerebral performance category (CPC) score 3-5)
- Follow-up
- Hospital discharge
Methodological detailsmulticentre
- Multicentre
Main finding
Poor neurologic outcome (CPC 3-5)
Odds ratio
2.50
95% CI 1.03–6.20
P = 0.04
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| In-hospital mortalityNT-proBNP above median vs NT-proBNP below median · multivariable adjusted | 2.30 (1.03–5.10) | P = 0.04 | |
| Poor neurologic outcome and mortality, by presenting rhythm (subgroup)NT-proBNP above median vs NT-proBNP below median · shockable rhythm: poor neurologic outcome | 7.80 (2.20–27.60) | P = 0.002 | |
| Poor neurologic outcome and mortality, by presenting rhythm (subgroup)NT-proBNP above median vs NT-proBNP below median · shockable rhythm: mortality | 5.90 (1.60–22.20) | P = 0.009 | |
| 0.050.21520Odds ratio (log scale) |
- Poor neurologic outcome and mortality, by presenting rhythm (subgroup): p-interaction = 0.01 (neurologic outcome) and 0.04 (mortality)
Median NT-proBNP (all patients) · within 24 h of ROSC
- Median NT-proBNP 1108 pg/mL (IQR 163-3482)
Poor neurologic outcome and mortality, by presenting rhythm (subgroup)
- No association among individuals with a non-shockable rhythm
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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