Oliceridine for postoperative pain and opioid-related complications: The intravenous oliceridine and opioid-related complications (VOLITION) prospective cohort study
Authors' conclusion
Nearly one quarter of patients experienced a respiratory compromise with oliceridine analgesia, none of which was life-threatening.
Study context
- Population
- Patients scheduled for major noncardiac surgery197 with cardiorespiratory data analysed
- Participants
- 204 patients
- Outcome
- Respiratory compromise
- Follow-up
- Initial two postoperative days
Methodological detailssingle-group, adjudicated respiratory events, Continuous monitoring with pulse oximetry, capnography and plethysmography, Respiratory events adjudicated by two independent expert reviewers
- Single-group
- Adjudicated respiratory events
- Continuous monitoring with pulse oximetry, capnography and plethysmography
- Respiratory events adjudicated by two independent expert reviewers
Main finding
As reported in the abstract
| Group | Value | Adjudicated episodes |
|---|---|---|
| Oliceridine | 23 % | 174 |
Oliceridine
Value23 %
Adjudicated episodes174
Observational data: associations, not effects.
Further findings
Complete gastrointestinal response (no vomiting and no rescue antiemetic use; exploratory)
- Patients with a complete gastrointestinal response
- 107 (53 %)
- Exploratory
Deaths, oliceridine-related serious AEs, naloxone reversal
- Naloxone opioid reversal never required
- 0
- No deaths or oliceridine-related serious adverse events
Safety
Delirium (screening criteria met)
- Patients meeting screening criteria for delirium
- 8
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Oliceridine for postoperative pain and opioid-related complications: The intravenous oliceridine and opioid-related complications (VOLITION) prospective cohort study. J Clin Anesth. Published 29 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →