Opioid-Sparing Anesthesia Versus Opioid-Free Anesthesia for the Prevention of Postoperative Nausea and Vomiting after Laparoscopic Bariatric Surgery: A Systematic Review and Network Meta-Analysis
Pooled result · Moderate-quality evidenceResult — go to the resultRelative risk 0.6 95% CI 0.5–0.9Authors' conclusion
OFA is more effective than OSA in reducing the occurrence of PONV during the early postoperative period of LBS, although it may associate with an increased risk of bradycardia.
Study context
- Population
- Patients undergoing laparoscopic bariatric surgery
- Participants
- 1,310 patients · 15 randomized controlled trials (RCTs)
- Comparison
- Opioid-free anesthesia vs opioid-sparing anesthesia
- Opioid-free anesthesia (OFA)n = 199
- Opioid-sparing anesthesia (OSA)n = 476reference
- Opioid-based anesthesia (OBA)n = 247
- Outcome
- Any PONV occurrence
- Follow-up
- Within 24 hours
Methodological detailsGrading of Recommendations Assessment, Development, and Evaluation (GRADE)
- GRADE
Pooled result
Moderate-quality evidence
Relative risk
0.6
95% CI 0.5–0.9
OFA vs OSA
RR 0.6 (95% CI 0.5–0.9)
As reported in the abstract
Further pooled results
Postoperative pain control and opioid consumption
- No differences between OFA and OSA
- Very low-to high-quality evidence
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| BradycardiaOFA vs OSA · moderate-quality evidence | 2.6 (1.2–5.9) | |
| 0.20.5125Relative risk (log scale) |
Original publication
Opioid-Sparing Anesthesia Versus Opioid-Free Anesthesia for the Prevention of Postoperative Nausea and Vomiting after Laparoscopic Bariatric Surgery: A Systematic Review and Network Meta-Analysis. Anesth Analg. Published 5 April 2024. doi:10.
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