Oral ketamine for acute postoperative analgesia (OKAPA) trial: A randomized controlled, single center pilot study
Authors' conclusion
This pilot study demonstrated that low dose oral ketamine can be safely used as an adjunct in postoperative pain treatment to help reduce opioid consumption after major spine surgery.
Study context
- Population
- Adults (18–75) undergoing multi-level lumbar spine decompression and fusion with planned overnight admission, Toronto Western Hospital, Canadaanalysed
- Participants
- 35 adults
- Comparison
- Oral ketamine 30 mg vs matching placebo for 3 days or until discharge
- Ketaminen = 18
- Placebon = 17reference
- Primary endpoint
- Patient-reported QoR-15 score
Methodological detailspilot, feasibility, prospective, single-centre, double-blinded, parallel arm, placebo-controlled
- Pilot
- Feasibility
- Prospective
- Single-centre
- Double-blinded
- Parallel arm
- Placebo-controlled
Primary result
As reported in the abstract
QoR-15 · POD 1, 3, 7 and 30
- No significant differences in QoR-15 scores at POD 1, 3, 7 and 30
Secondary outcomes
Pain intensity · POD 1, 3, 7 and 30
- No significant differences
PROMIS pain interference and PHQ-9 scores · POD 7 and 30
- No significant differences
Oral opioid use · POD 3 and by POD 7
- Significantly less oral opioids used with Ketamine vs Placebo
Days on oral opioids and hospital discharge
- Ketamine: significantly fewer days on oral opioids; trend to earlier hospital discharge
Original publication
Oral ketamine for acute postoperative analgesia (OKAPA) trial: A randomized controlled, single center pilot study. J Clin Anesth. Published 21 November 2024. doi:10.
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