Outcomes Related to New Persistent Opioid Use After Surgery or Trauma: A Population-based Cohort Study
Authors' conclusion
Among opioid-naive patients who received opioids after surgery or trauma, POU was associated with worse outcomes, including increased mortality.
Study context
- Population
- Opioid-naive patients dispensed opioids after discharge following admission for surgery or trauma to any New Zealand (NZ) hospital, 2007–2019298,928 surgical, 206,663 trauma
- Exposure
- Persistent opioid use (POU) vs no POU after surgery or trauma
- Outcome
- All-cause mortality
- Follow-up
- Between 180 and 360 days after discharge
Methodological detailspopulation-based, linked data, multivariable Cox and quantile regression
- Population-based
- Linked data
- Multivariable Cox and quantile regression
Main finding
As reported in the abstract
POU vs No POUAdjusted hazard ratio (95% CI)
Surgical
6.59(5.82–7.46)
Trauma
2.77(2.47–3.11)
Observational data: associations, not effects.
Secondary outcomes
POU incidence
| Outcome | aHR (95% CI) | |
|---|---|---|
| All-cause hospitalisationPOU vs No POU · surgical | 2.02 (1.95–2.08) | |
| All-cause hospitalisationPOU vs No POU · trauma | 1.57 (1.52–1.62) | |
| Opioid-related hospitalisationPOU vs No POU · surgical | 2.49 (2.24–2.76) | |
| Opioid-related hospitalisationPOU vs No POU · trauma | 1.89 (1.73–2.05) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Days Alive and Out of Hospital (DAOH)
- POU significantly associated with reduced DAOH
Original publication
Outcomes Related to New Persistent Opioid Use After Surgery or Trauma: A Population-based Cohort Study. Ann Surg. Published 27 August 2024. doi:10.
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