Oxygen and carbon dioxide targets after cardiac arrest: an updated systematic review
Authors' conclusion
Among patients resuscitated from cardiac arrest, neither restrictive oxygen targets nor mild hypercapnia, compared to conventional targets, improved survival or functional outcomes.
Study context
- Population
- Adults with sustained ROSC after cardiac arrest, primarily OHCA12 trials
- Comparison
- Restrictive vs liberal oxygen targets; mild hypercapnia vs normocapnia
- Outcome
- Survival and favourable functional outcomes
Methodological detailsrandom-effects models, GRADE methodology, 5 trials of oxygen targets prehospital; 6 of oxygen targets and 3 of carbon dioxide targets in the ICU
- Random-effects models
- GRADE methodology
- 5 trials of oxygen targets prehospital; 6 of oxygen targets and 3 of carbon dioxide targets in the ICU
Pooled result
As reported in the abstract
- No differences in survival or favourable functional outcomes, restrictive vs liberal oxygen targets, prehospital or ICU setting
- No difference in outcomes, mild hypercapnia vs normocapnia
- Certainty of evidence low to moderate
- Risk of bias moderate for most outcomes
Original publication
Oxygen and carbon dioxide targets after cardiac arrest: an updated systematic review. Resuscitation. Published 23 April 2025. doi:10.
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