Pain profiles and opioid consumption following joint replacement surgery: a prospective observational cohort study
Authors' conclusion
A discharge prescription of 60 opioid pills may be excessive for patients undergoing THA or TKA.
Study context
- Population
- Patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) at two centres in Toronto, ON, Canada
- Participants
- 443 patients
- Outcome
- Discharge opioid prescription, consumption, and pain after THA and TKA
- Follow-up
- Three months
Methodological detailstwo centres
- Two centres
Main finding
As reported in the abstract
- Opioid pill count prescribed at discharge, median [IQR]
- 60 [50-80]
- Participants with more than one-third of prescribed quantity remaining at 12 weeks
- 33.9%
- Pain relief appropriate at all follow-ups
- Three-quarters
- Incidence of neuropathic pain before TKA or THA
- 24.1%
- Incidence of neuropathic pain at 12 weeks
- 4.3%
Observational data: associations, not effects.
Further findings
Factors associated with higher opioid consumption · six weeks
| OR (95% CI) | P value | ||
|---|---|---|---|
| Female sex | 1.78 (1.08–2.95) | P = 0.03 | |
| Preoperative opioid use | 2.46 (1.25–5.1) | P = 0.01 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Factors associated with higher opioid consumption · six weeksTKA vs THA | 2.46 (1.47–4.17) | P = 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Pain profiles and opioid consumption following joint replacement surgery: a prospective observational cohort study. Can J Anaesth. Published 20 February 2025. doi:10.
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