Pediatric anesthesia & critical care
Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial
An erratum to this article was published (JAMA, 11 Apr 2023 ↗)
Authors' conclusion
Nasal high-flow oxygen used as the initial primary therapy in children aged 1 to 4 years with acute hypoxemic respiratory failure did not significantly reduce the length of hospital stay compared with standard oxygen therapy.
Study context
- Population
- Children aged 1 to 4 years requiring hospital admission for acute hypoxemic respiratory failure, 14 metropolitan and tertiary hospitals in Australia and New Zealand1,517 (97%) in primary analysis
- Participants
- 1,567 children
- Comparison
- Early high-flow nasal oxygen vs standard oxygen therapy
- High-flow oxygenn = 753
- Standard oxygenn = 764reference
- Primary endpoint
- Length of hospital stay
Methodological detailsmulticentre, investigators blinded until outcome data locked
- Multicentre
- Investigators blinded until outcome data locked
Primary result
As reported in the abstract
Adjusted hazard ratio
0.83
95% CI 0.75–0.92
P < 0.001
By group
High-flow oxygen vs Standard oxygen
adjusted HR 0.83 (95% CI 0.75–0.92); P < 0.001
Secondary outcomes
| Outcome | High-flow oxygen | Standard oxygen | Estimate | |
|---|---|---|---|---|
| Length of oxygen therapyMedian, days | 1.07 (IQR 0.50–2.06) | 0.75 (IQR 0.35–1.61) | aHR 0.78 (95% CI 0.70–0.86) | |
| ICU admission | 12.5% | 6.9% | aOR 1.93 (95% CI 1.35–2.75) | |
| 0.20.5125Ratio (log scale) |
Prespecified secondary outcomes
- Of the 9 prespecified secondary outcomes, 4 showed no significant difference
Death
- Only 1 death, in the high-flow oxygen group
Original publication
Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial. JAMA. Published 17 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →