Pediatric anesthesia & critical care
Patient Backgrounds and Outcomes of Mechanically Ventilated Children Treated in ICUs Versus General Wards in Japan: A Retrospective Cohort Study Using a National Inpatient Database
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 1.49 95% CI 1.35–1.65Authors' conclusion
Most of the children on mechanical ventilation in Japan were treated in general wards. The treatment of patients in general wards was associated with higher mortality than in ICUs
Study context
- Population
- Mechanically ventilated children ≤14 years hospitalized in general wards or ICUs, Japanese national inpatient database, July 2010–March 2022
- Participants
- 129,375 participants · 15,760 matched pairs
- Exposure
- General ward vs ICU treatment of mechanically ventilated children
- ICUn = 48,137reference
- Outcome
- In-hospital mortality
Methodological details1:1 propensity score matching, national inpatient database, multiple hospitals
- 1:1 propensity score matching
- National inpatient database
- Multiple hospitals
Main finding
As reported in the abstract
Odds ratio
1.49
95% CI 1.35–1.65
P < 0.001
By group
General ward vs ICU
OR 1.49 (95% CI 1.35–1.65); P < 0.001
Observational data: associations, not effects.
Further findings
Proportion treated in general wards
- All patients treated in general wards
- 63%
- Nonoperative patients treated in general wards
- 78%
- Postoperative patients treated in general wards
- 17%
- ICU patients who were postoperative
- 56%
- Postoperative ICU patients who underwent cardiac surgery
- 70%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Patient Backgrounds and Outcomes of Mechanically Ventilated Children Treated in ICUs Versus General Wards in Japan: A Retrospective Cohort Study Using a National Inpatient Database. Crit Care Med. Published 17 October 2025. doi:10.
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