Patient-centered results from a multicenter study of continuous peripheral nerve blocks and postamputation phantom and residual limb pain: secondary outcomes from a randomized, clinical trial
Authors' conclusion
Among patients with postamputation phantom pain, a continuous peripheral nerve block more than doubles the chance of a clinically relevant improvement in pain intensity.
Study context
- Population
- Patients with a limb amputation and phantom pain
- Participants
- 71 vs 73
- Comparison
- 6-day continuous peripheral nerve block with ropivacaine vs saline
- Ropivacainen = 71
- Salinen = 73reference
- Primary endpoint
- At least 2-point improvement on the 11-point NRS in average and worst phantom pain
- Follow-up
- 4 weeks postbaseline
Methodological detailsdouble-masked, multicentre
- Double-masked
- Multicentre
Primary result
As reported in the abstract
≥2-point NRS improvement in average and worst phantom pain · 4 weeks
| Group | Value | Average pain | Worst pain |
|---|---|---|---|
| Ropivacaine | 57% | ||
| Saline | 26% | 25% |
Value
Ropivacaine57%
Saline— not stated in the abstract
Average pain
Ropivacaine— not stated in the abstract
Saline26%
Worst pain
Ropivacaine— not stated in the abstract
Saline25%
- Ropivacaine vs Saline: P < 0.001 — average pain
- Ropivacaine vs Saline: P < 0.001 — worst pain
Further findings
Pain rated as improved (PGIC) · 4 weeks
1.7 (95% CI 1.1–2.7) · P = 0.008
Patient-defined small, medium and large improvements in phantom pain NRS (all patients) · 4 weeks
- Small: median (IQR) 2 (0-2)
- Medium: median (IQR) 3 (2-5)
- Large: median (IQR) 5 (3-7)
Patient-defined small, medium and large improvements in Brief Pain Inventory interference subscale (0-70)
- Small: median 8 (1-18)
- Medium: median 22 (14-31)
- Large: median 39 (26-47)
Original publication
Patient-centered results from a multicenter study of continuous peripheral nerve blocks and postamputation phantom and residual limb pain: secondary outcomes from a randomized, clinical trial. Reg Anesth Pain Med. Published 9 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →