The peak end-tidal carbon dioxide concentration recorded during cardiopulmonary resuscitation as an indicator of survival: a nationwide cohort study of pediatric out-of-hospital cardiac arrests
Study context
- Population
- Patients under 18 years with trauma-related or medical out-of-hospital cardiac arrest (OHCA), French RéAC OHCA registry, 2011 to 2023
- Participants
- 1,209 pediatric OHCAs
- Exposure
- Trauma-related OHCA vs Medical OHCA
- Trauma-related OHCAn = 226
- Medical OHCAn = 983
- Outcome
- ROSC and d30 survival
Methodological detailsregistry-based (French RéAC OHCA registry), prognostic accuracy (AUROC, Youden index)
- Registry-based (French RéAC OHCA registry)
- Prognostic accuracy (AUROC, Youden index)
Main finding
As reported in the abstract
Discrimination of highest ETCO2 for ROSC and d30 survival
| Group | AUROC for return of spontaneous circulation (ROSC) [95% CI] | AUROC for d30 survival [95% CI] | Optimal cut-off for ROSC | Optimal cut-off for d30 survival |
|---|---|---|---|---|
| Trauma-related OHCA | 0.808 [0.745-0.872] | 0.854 [0.761-0.947] | 21 mmHg | 29 mmHg |
| Medical OHCA | 0.803 [0.774-0.831] | 0.732 [0.676-0.787] | 27 mmHg | 26 mmHg |
AUROC for return of spontaneous circulation (ROSC) [95% CI]
Trauma-related OHCA0.808 [0.745-0.872]
Medical OHCA0.803 [0.774-0.831]
AUROC for d30 survival [95% CI]
Trauma-related OHCA0.854 [0.761-0.947]
Medical OHCA0.732 [0.676-0.787]
Optimal cut-off for ROSC
Trauma-related OHCA21 mmHg
Medical OHCA27 mmHg
Optimal cut-off for d30 survival
Trauma-related OHCA29 mmHg
Medical OHCA26 mmHg
Observational data: associations, not effects.
Further findings
ROSC and d30 survival, all pediatric OHCAs
- ROSC achieved
- 347 (29%)
- d30 survival
- 61 (5%)
Peak recorded ETCO2 by outcome
- In both trauma-related and medical OHCAs, peak ETCO2 higher in patients with ROSC and in d30 survivors
Original publication
The peak end-tidal carbon dioxide concentration recorded during cardiopulmonary resuscitation as an indicator of survival: a nationwide cohort study of pediatric out-of-hospital cardiac arrests. Resuscitation. Published 29 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →