Pediatric anesthesia & critical care

Pediatric Intensive Care Nurse Staffing Measures and Patient Outcomes During the COVID-19 Pandemic

JAMA Netw OpenPublished Retrospective cross-sectional study

An erratum to this article was published (JAMA Netw Open, 1 Aug 2025 ↗)

Authors' conclusion

In this cross-sectional study of nurse staffing measures and patient outcomes during COVID-19, complex associations existed throughout the study years.

Study context

Population
Patients younger than 19 years admitted to US pediatric intensive care units (PICUs) (PHIS and PROSPECT databases), 2019–2022admissions, 20 PICUs
Participants
218,789 participants
Exposure
Variable agency staffing vs Non-variable agency staffing
  • Variable agency staffingn = 120,017
  • Non-variable agency staffingn = 98,772reference
Outcome
Mortality, PICU complications, central line-associated bloodstream infections, or ventilator-associated pneumonias
Methodological detailsmulticentre, linked database
  • Multicentre
  • Linked database

Main finding

As reported in the abstract

PICU complications
GroupValueDenominator
Variable proportion of agency nurses8.1%120 017
Other PICUs7.2%98 772

Value

Variable proportion of agency nurses8.1%
Other PICUs7.2%

Denominator

Variable proportion of agency nurses120 017
Other PICUs98 772
  • Variable proportion of agency nurses vs Other PICUs: P < 0.001
Multivariable: increase in VAP per 10 000 ventilator-days in 2020
19 (95% CI, 7-39)
Per 10% higher nurse turnover than median: more PICU complications per 10 000 patient-days in 2022
10 (95% CI, 8-13)

Observational data: associations, not effects.

Further findings

VAP (multivariable analysis) · 2020

Increase in VAPs per 10 000 ventilator-days
19 (95% CI, 7-39)

PICU complications per 10% higher nurse turnover than median (multivariable analysis) · 2022

More PICU complications per 10 000 patient-days
10 (95% CI, 8-13)

Original publication

Pediatric Intensive Care Nurse Staffing Measures and Patient Outcomes During the COVID-19 Pandemic. JAMA Netw Open. Published 2 June 2025. doi:10.1001/jamanetworkopen.2025.15376

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