Perineuromal hydrodissection for acute postamputation pain? An observational study in a time of war
Authors' conclusion
This exploratory study suggests perineuromal hydrodissection may improve residual limb pain and to a lesser degree phantom limb pain, particularly when implemented early in the course of postamputation pain.
Study context
- Population
- Ukrainian patients with war-related limb amputations and painful neuroma(s)
- Participants
- 74 patients
- Exposure
- Perineuromal hydrodissection plus opioids vs opioids alone
- Hydrodissectionn = 38
- Opioid-onlyn = 36reference
- Outcome
- Co-primary: median reduction from baseline in average residual limb pain and PLP
- Follow-up
- 12 weeks
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
Reduction in average residual limb pain
Hydrodissection
−2.00
± 1.00
Opioid-only
−1.00
± 1.00
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Hydrodissection | Opioid-only | P value |
|---|---|---|---|
| HADS anxiety score · 12 weeks | 10.00 ± 2.00 | 11.00 ± 1.00 | P < 0.001 |
HADS anxiety score · 12 weeks
- HADS depression score not lower with hydrodissection
Opioid use (morphine equivalents per day), change over study
- Hydrodissection: declined from 41.32±9.63 to 33.42±8.78 morphine equivalents per day
- P = 0.001
- Opioid-only: no significant decline
- P = 0.20
Satisfaction · 12 weeks
- Differences in satisfaction rates not significant
Original publication
Perineuromal hydrodissection for acute postamputation pain? An observational study in a time of war. Reg Anesth Pain Med. Published 19 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →