Perioperative medicine & outcomes
Perioperative Changes in Blood Volume and Fluid Distribution in Total Hip Arthroplasty—A Protocol for a Prospective Single‐Center Observational Study
Study context
- Population
- Patients undergoing elective total hip arthroplasty (THA) in a standardized fast-track settingplanned enrollment
- Participants
- 25 patients
- Primary endpoint
- Change in total blood volume (carbon monoxide-rebreathing method)
- Follow-up
- From baseline to 6 h postoperatively
Methodological detailssingle-center, Blood volume by carbon monoxide rebreathing (total Hb mass, red cell, plasma and total blood volume); bioimpedance spectroscopy for intra-/extracellular fluid and total body water; measured at baseline, 6 h and 24 h postoperatively when feasible, Secondary outcomes: changes in Hb mass, fluid compartment shifts and their associations with postoperative orthostatic intolerance
- Single-center
- Blood volume by carbon monoxide rebreathing (total Hb mass, red cell, plasma and total blood volume); bioimpedance spectroscopy for intra-/extracellular fluid and total body water; measured at baseline, 6 h and 24 h postoperatively when feasible
- Secondary outcomes: changes in Hb mass, fluid compartment shifts and their associations with postoperative orthostatic intolerance
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Perioperative Changes in Blood Volume and Fluid Distribution in Total Hip Arthroplasty—A Protocol for a Prospective Single‐Center Observational Study. Acta Anaesthesiol Scand. Published 21 July 2026. doi:10.
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