Perioperative medicine & outcomes
Perioperative Factors Associated With Postoperative Delirium in Patients Undergoing Noncardiac Surgery: An Individual Patient Data Meta-Analysis
Authors' conclusion
In this systematic review and meta-analysis of individual patient data, several important factors associated with POD were found that may help identify patients at high risk
Study context
- Population
- Adults undergoing noncardiac surgery
- Participants
- 8,382 adults · 21 studies
- Outcome
- POD
- Follow-up
- Up to 10 days after procedure
Methodological details1-stage meta-analysis, multilevel mixed-effects logistic regression, multiple imputation by chained equations
- 1-stage meta-analysis
- Multilevel mixed-effects logistic regression
- Multiple imputation by chained equations
Pooled result
As reported in the abstract
POD incidence and associated perioperative factors
- Postoperative delirium (POD) incidence
- 18%
- ASA status 4, OR
- 2.43 (95% CI 1.42-4.14)
- Age 65-85 years, OR
- 2.67 (95% CI 2.16-3.29)
- Age >85 years, OR
- 6.24 (95% CI 4.65-8.37)
- BMI <18.5, OR
- 2.25 (95% CI 1.64-3.09)
- History of delirium, OR
- 3.9 (95% CI 2.69-5.66)
- Preoperative cognitive impairment, OR
- 3.99 (95% CI 2.94-5.43)
- Preoperative C-reactive protein 5-10 mg/dL, OR
- 2.35 (95% CI 1.59-3.50)
- Preoperative C-reactive protein >10 mg/dL, OR
- 3.56 (95% CI 2.46-5.17)
- College degree or higher, OR
- 0.45 (95% CI 0.28-0.72)
Original publication
Perioperative Factors Associated With Postoperative Delirium in Patients Undergoing Noncardiac Surgery: An Individual Patient Data Meta-Analysis. JAMA Netw Open. Published 2 October 2023. doi:10.
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