Perioperative medicine & outcomes
Perioperative intravenous fluid and chronic kidney disease: long-term follow-up of the Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) randomised trial
Primary result · New or worse CKD ≥ stage 3Result — go to the resultAdjusted odds ratio 1.13 95% CI 0.91–1.41Authors' conclusion
Within the limits of this post hoc analysis, no difference was found in the incidence of new or progressive CKD was not related to a restrictive perioperative fluid regimen.
Study context
- Population
- Major abdominal surgery patients in the RELIEF trial, followed 90 days to 48 months after surgeryof 2983 in mITT analysis
- Participants
- 1,670 patients
- Comparison
- Restrictive vs liberal perioperative IV fluid regimen
- Restrictiven = 754
- Liberaln = 766reference
- Primary endpoint
- Incident or progressive chronic kidney disease (CKD) (stage ≥3), incl. worsening by ≥1 CKD stage if preoperative CKD stage ≥3
- Follow-up
- Between 90 days and 48 months after surgery
Methodological detailslong-term follow-up, post hoc analysis, modified intention-to-treat
- Long-term follow-up
- Post hoc analysis
- Modified intention-to-treat
Primary result
New or worse CKD ≥ stage 3
Adjusted odds ratio
1.13
95% CI 0.91–1.41
Events by treatment group
Restrictive vs Liberal
aOR 1.13 (95% CI 0.91–1.41)
As reported in the abstract
Secondary outcomes
Lowest estimated glomerular filtration rate (eGFR) and maximal change in eGFR from baseline
- No differences for eGFR secondary outcomes
Original publication
Perioperative intravenous fluid and chronic kidney disease: long-term follow-up of the Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) randomised trial. Br J Anaesth. Published 23 June 2026. doi:10.
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